The MacColl Lab

University of Nottingham


Research outline: We are a whole organism evolutionary ecology lab. We are fascinated by the diversity of life. We are particularly interested in the ecological causes of, and genetic responses to, natural selection, especially in the context of the processes that drive adaptive radiation in contemporary wild populations. But some of us also do conservation biology. Mainly we study the three-spined stickleback, Gasterosteus aculeatus. Developments in genetic technology mean that the study of evolution is crossing the threshold of an extraordinary new period of discovery. Genome sequencing is rapidly revealing the proximate, genetic basis for trait variation and evolution.

There is also a massive opportunity to further our comprehension of the ultimate causes of evolution, which can only come from a better understanding of the ecological context in which evolution takes place. Advance in this area depends on the adoption of model systems that span the range of cutting-edge techniques from sequencing to manipulative ecological experiments. The three-spined stickleback provides such a system. We also do, or have done research on mammals, birds and aquatic insects. We combine observational ecology, analysis of long-term datasets, and field, lab and mesocosm experiments with quantitative and molecular genetics.

Lab news:

We have a new manuscript on Intercontinental genomic parallelism in multiple adaptive radiations in BioRxiv

Congratulations to Chris Heward, who has passed his PhD viva, on the ecology of woodcock, with minor corrections.

Recent lab papers include:
A paper in Science on how DNA fragility can elevate mutation rates and contribute to parallel evolution. *Now highly cited*.
A paper in Science on the effects of temperature and precipitation on natural selection. *Highly cited*.
Laura Dean's paper on admixture and speciation in stickleback in a stickleback, in Mol. Biol. Evol.
A collaboration with Daniel Berner's lab in Basel, documenting parallel adaptation to pH variation on North Uist, in Evolution Letters.
Laura Dean's description of a very rare case of internal fertilisation in a stickleback, published in Scientific Reports.
A first paper from the Isle of May wild mouse project! Immune variation is related to diet. Functional Ecology.
Jim Whiting's paper in Mol. Ecol., looking at correlations between life history and immune system activity in three-spined stickleback.
Abdul Rahman Singkam's paper in Journal of Fish Biology, on the correct way to determine stickleback age using otolith ear bones.
Chris Heward published an analysis of the habitat correlates of native woodcock, a declining bird species in the UK, in J. Ornithology.
A meta-analysis of environmental determinants of natural selection, in American Naturalist.


School of Life Sciences, University of Nottingham, University Park, Nottingham, NG7 2RD, U.K.

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Funders: NERC, BBSRC, NESCent, FSBI, The Leverhulme Trust

External links:
School of Life Sciences
Behaviour and Ecology Group, Nottingham,